Variable t-tubule organization and Ca homeostasis across the atria
نویسندگان
چکیده
Michael Frisk, Jussi T. Koivumäki, Per A. Norseng, Mary M. Maleckar, Ole M. Sejersted, and William E. Louch Institute for Experimental Medical Research, Oslo University Hospital and University of Oslo, Oslo, Norway; KG Jebsen Cardiac Research Center and Center for Heart Failure Research, University of Oslo, Oslo, Norway; Center for Biomedical Computing, Simula Research Laboratory, Oslo, Norway; and Center for Cardiological Innovation, Oslo University Hospital, Oslo, Norway
منابع مشابه
Variable t-tubule organization and Ca2+ homeostasis across the atria.
Although t-tubules have traditionally been thought to be absent in atrial cardiomyocytes, recent studies have suggested that t-tubules exist in the atria of large mammals. However, it is unclear whether regional differences in t-tubule organization exist that define cardiomyocyte function across the atria. We sought to investigate regional t-tubule density in pig and rat atria and the consequen...
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Efficient intracellular Ca²⁺ ([Ca²⁺]i) homeostasis in skeletal muscle requires intact triad junctional complexes comprised of t-tubule invaginations of plasma membrane and terminal cisternae of sarcoplasmic reticulum. Bin1 consists of a specialized BAR domain that is associated with t-tubule development in skeletal muscle and involved in tethering the dihydropyridine receptors (DHPR) to the t-t...
متن کاملTransverse tubules are a common feature in large mammalian atrial myocytes including human.
Transverse (t) tubules are surface membrane invaginations that are present in all mammalian cardiac ventricular cells. The apposition of L-type Ca(2+) channels on t tubules with the sarcoplasmic reticulum (SR) constitutes a "calcium release unit" and allows close coupling of excitation to the rise in systolic Ca(2+). T tubules are virtually absent in the atria of small mammals, and therefore Ca...
متن کاملElevated ventricular wall stress disrupts cardiomyocyte t-tubule structure and calcium homeostasis
AIMS Invaginations of the cellular membrane called t-tubules are essential for maintaining efficient excitation-contraction coupling in ventricular cardiomyocytes. Disruption of t-tubule structure during heart failure has been linked to dyssynchronous, slowed Ca(2+) release and reduced power of the heartbeat. The underlying mechanism is, however, unknown. We presently investigated whether eleva...
متن کاملCharacterization of an extensive transverse tubular network in sheep atrial myocytes and its depletion in heart failure.
BACKGROUND In ventricular myocytes, the majority of structures that couple excitation to the systolic rise of Ca(2+) are located at the transverse tubular (t-tubule) membrane. In the failing ventricle, disorganization of t-tubules disrupts excitation contraction coupling. The t-tubule membrane is virtually absent in the atria of small mammals resulting in spatiotemporally distinct profiles of i...
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تاریخ انتشار 2014